Asthma-COPD overlap: current understanding and the utility of experimental models
نویسندگان
چکیده
منابع مشابه
The Asthma-COPD Overlap Syndrome.
Although in textbooks asthma and chronic obstructive pulmonary disease (COPD) are viewed as distinct disorders, there is increasing awareness that many patients have features of both. This article reviews the asthma-COPD overlap syndrome.
متن کاملThe Asthma-COPD Overlap Syndrome
Asthma and Chronic Obstructive Pulmonary Disease (COPD) are pulmonary disorders characterized by various degrees of airflow limitation, inflammation and tissue remodeling. Bronchial asthma, an allergic disease that develops in childhood, is physiologically characterized by reversible airflow obstruction. It has an episodic course and a generally favorable prognosis, as it responds well to anti-...
متن کاملAsthma-COPD overlap syndrome and precision medicine.
Differentiation of asthma and chronic obstructive pulmonary disease (COPD) in symptomatic patients has been extremely difficult clinically in many instances. This situation led to the formulation of the so-called “Dutch hypothesis” in 1961,1 cited by Christenson.2 The theory postulates that obstructive lung disease occur in a continuum, with asthma and COPD being expressions of the same disease...
متن کاملHeterogeneity of asthma–COPD overlap syndrome
Many patients suffering from asthma or COPD have overlapping features of both diseases. However, a phenotypical approach for evaluating asthma-COPD overlap syndrome (ACOS) has not been established. In this report, we examined the phenotypes in patients with ACOS. Patients diagnosed with ACOS between 2011 and 2015 were identified and classified into four phenotype groups. Group A was composed of...
متن کاملSputum cell count: biomarkers in the differentiation of asthma, COPD and asthma–COPD overlap
INTRODUCTION Cell count in induced sputum is a noninvasive biomarker to assess airway inflammation phenotypes. Accordingly, sputum cell counts are extensively used in the treatment of asthma and COPD. Nevertheless, the clinical application of sputum cell counts in patients with asthma-COPD overlap (ACO) remains elusive. The aim of this study was to investigate sputum cell counts in patients wit...
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ژورنال
عنوان ژورنال: European Respiratory Review
سال: 2021
ISSN: 0905-9180,1600-0617
DOI: 10.1183/16000617.0185-2019